Trazodone is a better option for persons with depressive disorder.As quetiapine has mood-stabilizing properties, it may be preferable choice for bipolar disorder.Therefore, titration of the maintenance (PCA) dose, based on objective caregiver assessment of pain, is the cornerstone of PCA therapy.Patient weight is a useful on which to base the PCA dose, even though the correlation between analgesic requirement and weight is poor.Trazodone: "off-label" sleeping pill Trazodone hcl is a sedating antidepressant with significant anxiolytic and sedative activity.In practice it is widely used off-label to treat insomnia.Seizures have occurred after less than twenty-four hours of meperidine with less than 400mg Loading Dose The loading dose accelerates attainment of an effective blood level of the opioid at the initiation of therapy or for procedures.Since there is marked inter-patient variability in the amount of analgesic required for pain relief, the loading dose must be titrated to effect.
However its advantage is that unlike most sleeping pills, it is not addictive and not habit forming.
However, at week 2 zolpidem shortened time to fall asleep greater than trazodone.
Trazodone versus Quetiapine (Seroquel®) The observational study compared and contrasted the efficacy of trazodone and quetiapine (Seroquel), an atypical antipsychotic, for insomnia in persons with with mental illness.
Trazodone's hypnotic properties are due to its antihistaminergic effects at the histamine-1 receptor, alpha 1-adrenergic receptor antagonism, and serotonin 5-HT2 receptor antagonism.
Patient-controlled analgesia (PCA) is a method of providing analgesia using a computerized pump that allows patients to self-administer predetermined doses of opioids.